Protein name:
Apoptosis regulator Bcl-2 ;
Alternative:
Organism:
Dog (Canis familiarisCanis lupus familiaris).
General Annotation
Sub Unit:
Forms homodimers, and heterodimers with BAX, BAD, BAK and Bcl-X(L). Heterodimerization with BAX requires intact BH1 and BH2 motifs, and is necessary for anti-apoptotic activity. Also interacts with FKBP8, APAF1, RAF-1, TP53BP2, BBC3, BCL2L1, MRPL41 and BNIPL. Interacts with BAG1 in an ATP-dependent manner.
Function:
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).
Subcellular Location:
Mitochondrion outer membrane
Single-pass membrane protein
Nucleus membrane
Single-pass membrane protein
Endoplasmic reticulum membrane
Single-pass membrane protein
Protein Attributes:
50:
MAQAGRTGYD | NREIVMKYIH | YKLSQRGYEW | DVGDVDAAPL | GAAPTPGIFS |
100:
FQPESNPTPA | VHRDMAARTS | PLRPIVATTG | PTLSPVPPVV | HLTLRRAGDD |
150:
FSRRYRRDFA | EMSSQLHLTP | FTARGRFATV | VEELFRDGVN | WGRIVAFFEF |
200:
GGVMCVESVN | REMSPLVDNI | ALWMTEYLNR | HLHTWIQDNG | GWDAFVELYG |
236:
PTMQPLFDFS | WLSLKALLSL | ALVGACITLG | AYLGHK
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Bovine
Human
Mouse
Chicken
Dog
ELISA Kit for Dog Apoptosis regulator Bcl-2
ELISA Kit for Dog Apoptosis regulator Bcl-2
ELISA Kit for Dog Apoptosis regulator Bcl-2
ELISA Kit for Dog Apoptosis regulator Bcl-2
ELISA Kit for Dog Apoptosis regulator Bcl-2
ELISA Kit for Dog Apoptosis regulator Bcl-2
CLIA Kit for Dog Apoptosis regulator Bcl-2
CLIA Kit for Dog Apoptosis regulator Bcl-2
CLIA Kit for Dog Apoptosis regulator Bcl-2
CLIA Kit for Dog Apoptosis regulator Bcl-2
CLIA Kit for Dog Apoptosis regulator Bcl-2
CLIA Kit for Dog Apoptosis regulator Bcl-2
Polyclonal Antibody for Dog Apoptosis regulator Bcl-2
Polyclonal Antibody for Dog Apoptosis regulator Bcl-2
Polyclonal Antibody for Dog Apoptosis regulator Bcl-2
Polyclonal Antibody for Dog Apoptosis regulator Bcl-2
Polyclonal Antibody for Dog Apoptosis regulator Bcl-2
Polyclonal Antibody for Dog Apoptosis regulator Bcl-2
Monoclonal Antibody for Dog Apoptosis regulator Bcl-2
Monoclonal Antibody for Dog Apoptosis regulator Bcl-2
Monoclonal Antibody for Dog Apoptosis regulator Bcl-2
Monoclonal Antibody for Dog Apoptosis regulator Bcl-2
Monoclonal Antibody for Dog Apoptosis regulator Bcl-2
Monoclonal Antibody for Dog Apoptosis regulator Bcl-2
Protein for Dog Apoptosis regulator Bcl-2
Protein for Dog Apoptosis regulator Bcl-2
Protein for Dog Apoptosis regulator Bcl-2
Protein for Dog Apoptosis regulator Bcl-2
Protein for Dog Apoptosis regulator Bcl-2
Protein for Dog Apoptosis regulator Bcl-2
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
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Cited for : NUCLEOTIDE SEQUENCE [MRNA]